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Smoking and inhalation of vaporized cannabis have better absorption than do other routes of administration, and therefore also have more predictable distribution.
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 a 2014 review found limited and weak evidence that smoked cannabis was effective for chronic non-cancer pain.
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 thc is highly protein bound once absorbed, with only 3% found unbound in the plasma.
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 inhaled and vaporized thc have similar absorption profiles to smoked thc, with a bioavailability ranging from 10 to 35%.
There is serious suspicion among cardiologists, spurring research but falling short of definitive proof, that cannabis use has the potential to contribute to cardiovascular disease.
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 regular cannabis use has not been shown to cause significant abnormalities in lung function.
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 thc further distributes into fatty tissues a few days after administration due to its high lipophilicity, and is found deposited in the spleen and fat after redistribution.
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 another 2015 review found limited evidence that medical cannabis was effective for neuropathic pain when combined with traditional analgesics.